Interstitial Pneumonia in Dermatomyositis
نویسندگان
چکیده
Dermatomyositis (DM) and polymyositis (PM) are types of autoimmune inflammatory muscle disease that mainly damage proximal limb muscles, with DM involving characteristic skin findings such as Gottron's sign and heliotrope eruption (Bohan & Peter, 1975a, 1975b). Interstitial pneumonia (IP) is often associated with DM/PM and is one of the important prognostic factors. Above all, rapidly progressive IP (RPIP), which has the worst prognosis, is resistant to corticosteroid drugs and is strongly associated with clinical amyopathic DM (CADM), which is unlikely to show myositis (Kameda & Takeuchi, 2006). In response, combination therapies of corticosteroid drugs and immunosuppressive drugs have recently been administered early in the onset of IP, and outcomes have been improved. Here, we review the pathogenesis, the clinical and laboratory findings, and treatment of IP associated with DM/PM.
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